Gene Expression Study of Individuals with Sex Chromosome Aneuploidies
Study Type:
Other
Abstract: Males and females show dramatic differences in their vulnerability to the same diseases. For example, compared to men, lupus is six times more prevalent in women, thyroid cancer is three times more prevalent, and unipolar depression is twice as prevalent. Diseases with a strong male bias include autism (5:1), dilated cardiomyopathy (3:1), and ankylosing spondylitis (5:1). Historically, such differences have been attributed solely to extrinsic factors such as circulating sex hormones or environmental influences. We hypothesize that intrinsic factors _ genetic differences between XX and XY cells _ have unappreciated biological consequences throughout the body and contribute to sex differences in disease incidence and severity. This hypothesis stems from our long-term effort to sequence... (for more see dbGaP study page.)
The SRA runs contain human sequence
These data are available through the dbGaP authorized access system.