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Effect of Notch Signaling Inhibitor on Gene Expression in Lipopolysaccharide-stimulated Macrophages in the Presence of Immune Complex

Identifiers: SRA: SRP144516
BioProject: PRJNA454891
GEO: GSE114020
Study Type: 
Transcriptome Analysis
Abstract: Lipopolysaccharide (LPS)/immunue complex (IC) stimulated macrophages produce cytokine profiles that differe from LPS-stimulated inflammatory macropahges. Notch signaling is activated in LPS/IC-stimulated macrophages and inhibition of Notch signaling reduced IL-10 production. This study investigated the effect of gamma-secretase inhibitor (GSI) that suppresses Notch signaling pathway, on gene expression profiles in macrophages activated by LPS/IC. Overall design: Gamma secretase inhibitor (GSI)-treated bone marrow derived macrophage mRNA profiles were generated by deep sequencing using Illumina NextSeq 500. The results were compared between vehicle control (dimethylsulfoxide)-treated cells and GSI-treated cells.
Center Project: GSE114020
External Link: /pubmed:29889863

Related SRA data

16 ( 16 samples )
16 (31.3Gbp; 13.5Gb)
Additional objects:
File type count
fastq 16