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Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

Identifiers: SRA: SRP063477
BioProject: PRJNA295101
GEO: GSE72815
Study Type: 
Transcriptome Analysis
Abstract: Here we present an RNAseq analysis of human bone samples, obtained from iliac crest needle biopsies, to yield the first in vivo interrogation of all genes and pathways that may be altered in bone with aging and E therapy in humans. Overall design: 58 healthy women were studied, including 19 young women (mean age ± SD, 30.3 ± 5.4 years), 19 old women (73.1 ± 6.6 years), and 20 old women treated with 3 weeks of E therapy (70.5 ± 5.2 years). Using generally accepted criteria (false discovery rate [q] < 0.10), aging altered a total of 678 genes and 12 pathways, including a subset known to regulate bone metabolism (e.g., Notch).
Center Project: GSE72815
External Link: /pubmed:26402159

Related SRA data

58 ( 58 samples )
58 (365.4Gbp; 161.5Gb)