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RNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients

Identifiers: SRA: SRP061881
BioProject: PRJNA291597
GEO: GSE71595
Study Type: 
Transcriptome Analysis
Abstract: Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and preferentially reduced disease-associated gene expression, including cytokine-related processes. Overall design: RNA-sequencing of CD4+ memory/effector T cells derived from Healthy Controls (HC) and JIA patients upon JQ1 treatment.
Center Project: GSE71595
External Link: /pubmed:26387944

Related SRA data

Experiments:
14 ( 14 samples )
Runs:
56 (19.9Gbp; 8.1Gb)