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Next Generation Sequencing Identification of HBV-MLL4 integration and its molecular basis in Chinese hepatocellular carcinoma

Identifiers: SRA: SRP056696
BioProject: PRJNA279878
GEO: GSE65485
Study Type: 
Transcriptome Analysis
Abstract: Purpose: To gain molecular insights of HBV integration that may contribute to HCC tumorigenesis, we performed whole transcriptome sequencing and whole genome copy number profiling of hepatocellular carcinoma (HCC) samples from 50 Chinese patients. Results: We identified a total of 33 HBV-human integration sites in 16 of 44 HBV-positive HCC tissues, which were enriched in HBV genotype C-infected patients. In addition, significantly recurrent HBV-MLL4 integration (18%; 8/44) was found in this cohort of patients. Conclusions: This is the first report on the molecular basis of the MLL4 integration driving MLL4 over-expression. HBV-MLL4 integration occurred frequently in Chinese HCC patients, representing a unique molecular segment for HCC with HBV infection. Overall design: mRNA profiles of 50 Chinese Hepatocellular Carcinoma patients and 5 adjacent tissues by Illumina Hiseq 2000.
Center Project: GSE65485
External Link: /pubmed:25901726

Related SRA data

55 ( 55 samples )
55 (808.8Gbp; 530.8Gb)