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Fat Regulatory T Cells Drive Age-Associated Insulin Resistance

Identifiers: SRA: SRP053799
BioProject: PRJNA275010
Study Type: 
Transcriptome Analysis
Abstract: We show that fat-resident regulatory T cells, termed fTregs, drive age-associated insulin resistance and can be specifically depleted to increase adipose insulin sensitivity. Comparative AdipoImmune profiling in young, aged, and obese mice reveals that fTregs progressively enrich in adipose as a function of age, but not obesity. fTreg-deficient mice are protected from age-associated insulin resistance and its accompanying physiological hallmarks. In contrast, fTreg-deficiency offers no protection from obesity-associated insulin resistance.

Related SRA data

10 ( 10 samples )
10 (34.3Gbp; 22.6Gb)