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Induction of circular RNA in fetal heart development recapitulated in in vitro differentiation

Identifiers: SRA: SRP051472
BioProject: PRJNA270993
GEO: GSE64417
Study Type: 
Transcriptome Analysis
Abstract: We discovered induction of circular RNA in human fetal tissues, including the heart. In this study, we were able to recapitulate this induction by in vitro directed differentiation of hESCs to cardiomyocytes, paving the way for future studies into circular RNA regulation. Overall design: We harvested hESCs at sequential stages of differentiation: undifferentiated (day 0), mesoderm (day 2), cardiac progenitor (day 5) and definitive cardiomyocyte (day 14). We performed RNA sequencing in biological triplicate, with 3-8 technical replicates each.
Center Project: GSE64417
External Link: /pubmed:26076956

Related SRA data

Experiments:
71 ( 71 samples )
Runs:
71 (53.0Gbp; 35.5Gb)