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MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

Identifiers: SRA: SRP044668
BioProject: PRJNA255754
GEO: GSE59612
Study Type: 
Transcriptome Analysis
Abstract: We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts to treat normal pressure hydrocephalus. We then used RNA-Seq to compare expression patterns between geographically distinct regions of gliomas and computational deconvolution to estimate cell type-specific expression patterns in different disease subtypes. Overall design: RNA-Seq analysis in 39 contrast-enhancing glioma core samples, 36 non-enhancing FLAIR glioma margin samples, and 17 non-neoplastic brain tissue samples.
Center Project: GSE59612
External Link: /pubmed:25114226

Related SRA data

Experiments:
92 ( 92 samples )
Runs:
94 (264.6Gbp; 172.4Gb)