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The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers

Identifiers: SRA: SRP043078
BioProject: PRJNA252112
GEO: GSE58365
Study Type: 
Transcriptome Analysis
Abstract: Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. Overall design: RNAseq was performed in endogenous BCL6-depleted OCI-LY1 cells rescued with either WT or RD mutant BCL6 (N=3 for each group).
Center Project: Homo sapiens
External Link: /pubmed:25176650

Related SRA data

Experiments:
6 ( 6 samples )
Runs:
6 (15.6Gbp; 10.4Gb)
Additional objects:
File type count
fastq 6