skip to main content

Overexpression of UHRF1 drives DNA hypomethylation and hepatocellular carcinoma

Identifiers: SRA: SRP033231
BioProject: PRJNA229468
GEO: GSE52605
Study Type: 
Transcriptome Analysis
Abstract: UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Using transgenic zebrafish, cultured cells and human tumors, we demonstrate that UHRF1 is an oncogene. RNAseq was used to assess the variation in gene expression between control and experimental samples. Overall design: Total small RNA from 2 batches of Tg(fabp10:has.UHRF1-GFP)High and age matched Tg(fabp10:nls-mCherry) control 5 dpf zebrafish livers was purified for preparation of high-throughput sequencing libraries.
Center Project: GSE52605
External Link: /pubmed:24486181

Related SRA data

Experiments:
4 ( 4 samples )
Runs:
4 (8.8Gbp; 5.2Gb)
Additional objects:
File type count
fastq 4