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Swedish Schizophrenia Population-Based Case-control Exome Sequencing

Identifiers: SRA: SRP011949
BioProject: PRJNA157243
dbGaP: phs000473
Study Type: 
Submission: SRA051415
Abstract: Current findings of the genetic risk of schizophrenia and bipolar disorder emerging from genome wide association studies (GWAS) support a highly polygenic model displaying the full spectrum of causal alleles that includes the extremes of rare, penetrant alleles as well as common alleles of small effect. Lower frequency polymorphism, rare variants and private mutations have eluded measurement by GWAS studies and thus association with disease. In order to create a comprehensive catalogue of low frequency or rare coding variation in individuals with psychiatric disease and to build a foundation for future genetic studies of schizophrenia and bipolar disorder, we have obtained whole exome DNA sequence from a population-based schizophrenia and bipolar disorder Swedish case-control cohort.

The SRA runs contain human sequence

These data are available through the dbGaP authorized access system.

Related SRA data

12380 (94.9Tbp; 42.2Tb)