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Mast Cell Leukemia Exome Sequencing

Identifiers: SRA: SRP008740
COLD SPRING HARBOR LABORATORY: mast cell leukemia
Study Type: 
Exome Sequencing
Abstract: Mast cell leukemia is a rare form of acute myeloid leukemia. Few genomic alterations are currently known. To identify novel determinants, we performed exome capture on DNA from a mast cell leukemia patient’s leukemic cells and matched germline using the SeqCap EZ Human Exome Library v2.0, (Roche NimbleGen; Madison, WI, USA) followed by deep sequencing on a Genome Analyzer IIx (Illumina; San Diego, CA, USA). We identified several missense mutations, at least two of which have diagnostic and therapeutic clinical implications.

Related SRA data

Experiments:
2 ( 2 samples )
Runs:
2 (10.6Gbp; 5.9Gb)