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Genentech whole-genome sequencing of a non-small cell lung carcinoma

Identifiers: SRA: SRP002045
BioProject: PRJNA74845
dbGaP: phs000299
Study Type: 
Submission: SRA012097 on 2010-03-03 16:42:00
Abstract: Version 1. Whole genome sequencing was applied to tumor and adjacent normal lung tissue in an individual non-small-cell lung cancer patient. We present an analysis of somatic changes identified throughout the tumor genome, including single-nucleotide variants, copy number variants, and large-scale chromosomal rearrangements. Over 50,000 high-confidence single-nucleotide variants were identified, revealing evidence of substantial smoking-related DNA damage as well as distinct mutational pressures within the tumor resulting in uneven distribution of somatic mutations across the genome. Version 2. Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and 3 lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra to human tumor samples... (for more see dbGaP study page.)

The SRA runs contain human sequence

These data are available through the dbGaP authorized access system.

Related SRA data

234 (8.4Tbp; 5.8Tb)