skip to main content

Exomes of human leukemic JMML (Juvenile MyeloMonocytic Leukemia) xenografts in NSG or NSG-S mice (samples enriched in hCD45)

Identifiers: SRA: ERP106674
BioProject: PRJEB24819
Assistance Publique des Hopitaux de Paris (AP-HP), Hopital Robert Debre, Departement de Genetique, Paris, France: E-MTAB-6467
Study Type: 
Other
Abstract: The study includes 14 patients with confirmed JMML and known somatic mutations (from exome data of paired tumoral and germline DNA). Bone marrow or peripheral blood mononucleated cells were injected in immundeficient mice to recapitulate the leukemia. Whole exome sequencing was performed in xenograft samples to control the persistance of patients' known mutations and look for new mutations acquired in xenograft sample.
Description: The study includes 14 patients with confirmed JMML and known somatic mutations (from exome data of paired tumoral and germline DNA). Bone marrow or peripheral blood mononucleated cells were injected in immundeficient mice to recapitulate the leukemia. Whole exome sequencing was performed in xenograft samples to control the persistance of patients' known mutations and look for new mutations acquired in xenograft sample.
External Link: E-MTAB-6467 in ArrayExpress

Related SRA data

Experiments:
26 ( 26 samples )
Runs:
26 (252.9Gbp; 91.9Gb)
Additional objects:
File type count
fastq 52