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Whole-exome sequencing of circulating tumor cells (CTCs) and CTCs associated to white blood cells

Identifiers: SRA: ERP106461
BioProject: PRJEB24623
UNIVERSITY OF BASEL: ena-STUDY-UNIVERSITY OF BASEL-25-01-2018-12:08:17:169-8
Study Type: 
Other
Abstract: Circulating tumor cells (CTCs) are precursors of metastasis in several cancer types, and are occasionally found within the bloodstream in association with non-malignant cells such as white blood cells (WBCs). The identity and function of these CTC-associated WBCs, as well as the molecular features that define the interaction between WBCs and CTCs are unknown. Here, we achieve the isolation and interrogation of individual CTC-associated WBCs, alongside with corresponding cancer cells within each CTC-WBC-cluster, from multiple breast cancer patients and mouse models.
Description: Circulating tumor cells (CTCs) are precursors of metastasis in several cancer types, and are occasionally found within the bloodstream in association with non-malignant cells such as white blood cells (WBCs). The identity and function of these CTC-associated WBCs, as well as the molecular features that define the interaction between WBCs and CTCs are unknown. Here, we achieve the isolation and interrogation of individual CTC-associated WBCs, alongside with corresponding cancer cells within each CTC-WBC-cluster, from multiple breast cancer patients and mouse models.

Related SRA data

Experiments:
639 ( 222 samples )
Runs:
639 (883.3Gbp; 377.5Gb)
Additional objects:
File type count
fastq 1278